chi-DrugStorePhoto Walgreens has about 8,200 stores, and Rite Aid about 4,500, making a combination much larger than CVS.

CHICAGO—Reversing a long-term trend, cap rates for single tenant CVS, Rite Aid and Walgreens properties all increased significantly in the third quarter of 2016, according to a new report by the Boulder Group, a net lease firm in suburban Chicago. Investors seem most concerned by US antitrust regulators’ requirement that Walgreens sell between 500 and 1,000 stores before they will approve its plan to acquire Rite Aid.