WeWork San Francisco is the home of co-working, most notably with the expansion of WeWork (credit: Twitter).

SAN FRANCISCO—South of Market has the most flexible workspace centers, while the Financial District is the most expensive in the city with an average monthly cost-per-desk of $1,500, according to new research by workspace innovation company, The Instant Group. The average desk cost in other areas of the city include Nob Hill at $1,192, South of Market at $998 and downtown at $950.