The Philadelphia-based PolyMedix Inc. has signed a 12-year lease for 24,223 sf at 170 N. Radnor Chester Rd. This takes occupancy in the 69,787-sf building, which was vacant at the end of 2005, to 75%. The biotech firm will take occupancy in December. The aggregate value of the lease is undisclosed. Six months ago, David Ryder, SVP and Western regional director of the Plymouth Meeting-based Brandywine, told GlobeSt.com that rent rates for all buildings in the complex, except the flagship 555 Lancaster Avenue building, were between $26.50 per sf and $28.50 per sf.

Enterprise Leasing Co. of Philadelphia, a car rental company, has signed a lease for 28,355 sf of office space and an additional 650 sf of storage space at the neighboring 150 Radnor Chester Road building. This is a structure of six connected buildings aggregating 335,450 sf.

Meanwhile, Brandywine has invested approximately $25 million in base building and tenant finishes into the 242,000-sf 555 Lancaster Ave. building to reposition it for a combination of retail and office space. Office rent rates at year-end 2005, according to Ryder, were between $30 per sf and $32 per sf. Philadelphia restaurateur Suzanna Foo has taken 7,500 sf for an upscale restaurant, and Philadelphia Sports Club has leased 42,000 sf for a sports facility. Office leases include a 57,000-sf commitment from Aon Corp.