CardioKine inks a five-year lease for 10,313 sf, the entire 15thfloor of the Graham Building at One Penn Square West in the MarketWest submarket. The pharmaceutical company that focuses on heartfailure prevention and treatment is relocating and expanding fromits current 5,000-sf headquarters in the University Science Centerat 3701 Market St.

George Cauffman and Nicholas Gersbach of the local office of CBRichard Ellis represented building owner, Washington, DC-basedMulti-Employer Property Trust. H. Hetherington Smith, SVP andbranch manager, and Margo Mocarski, an assistant director in thelocal office of Studley represented the tenant. Terms of the leaseare undisclosed. According to a first-quarter 2005 report by CBRE'soffice here, the average asking rental rate for Market West spaceis $24.46 per sf. However, office brokers report that discountingis rampant, often taking rates nearer the $20-per-sf level.

Wilkes and Hughes, a legal services firm, leases 6,275 sf at OneLiberty Place, the 61-story Center City trophy tower at 1650 MarketSt. William Hirschfeld and Sun Park of the local office of Cushman& Wakefield brokered the transaction.