The Philadelphia-based PolyMedix Inc. has signed a 12-year leasefor 24,223 sf at 170 N. Radnor Chester Rd. This takes occupancy inthe 69,787-sf building, which was vacant at the end of 2005, to75%. The biotech firm will take occupancy in December. Theaggregate value of the lease is undisclosed. Six months ago, DavidRyder, SVP and Western regional director of the PlymouthMeeting-based Brandywine, told GlobeSt.com that rent rates for allbuildings in the complex, except the flagship 555 Lancaster Avenuebuilding, were between $26.50 per sf and $28.50 per sf.

Enterprise Leasing Co. of Philadelphia, a car rental company,has signed a lease for 28,355 sf of office space and an additional650 sf of storage space at the neighboring 150 Radnor Chester Roadbuilding. This is a structure of six connected buildingsaggregating 335,450 sf.

Meanwhile, Brandywine has invested approximately $25 million inbase building and tenant finishes into the 242,000-sf 555 LancasterAve. building to reposition it for a combination of retail andoffice space. Office rent rates at year-end 2005, according toRyder, were between $30 per sf and $32 per sf. Philadelphiarestaurateur Suzanna Foo has taken 7,500 sf for an upscalerestaurant, and Philadelphia Sports Club has leased 42,000 sf for asports facility. Office leases include a 57,000-sf commitment fromAon Corp.