BOSTON- The University of Massachusetts proposes developing an 80,000-sf drug laboratory in the neighborhood of Mattapan, on a site once occupied by the former Boston State Hospital. The university says that its other drug production facility in nearby Jamaica Plain is at capacity.

BOSTON- Oracle Corporation, one of the world's largest software companies, and Donnelly, Conroy & Gelhaar, LLP, a law firm, lease space at One Beacon Street, a 34-story, one million sf Class A office tower located here in the heart of the city's financial district.

MATTAPAN, MA-This neighborhood a few miles from the city could be home to a 340-unit affordable housing project in the near future as the city's Greater Boston Interfaith Organization and Nehemiah Housing explore various city-owned parcels here as potential sites for the project.

CAMBRIDGE, MA- Akamai Technologies, Inc. terminates its lease for 234,000-sf of office space here, in an effort to take advantage of the current lower lease rates. The Internet company estimates that it will save as much as $8 million to $10 million a year by relocating.

BOSTON-Cambridge, MA-based Lyme Properties, in collaboration with the Harvard Institute of Medicine, proposes the development of a 400,000-sf biomedical research building here. The property would be located in the Longwood Medical Area.

BOSTON-The Boston Redevelopment Authority allows FleetBoston Pavilion to extend the lease on its four-acre waterfront site. The agency tells GlobeSt.com that if a more suitable tenant comes along it will give FleetBoston a year's notice before terminating its lease.

NORWOOD, MA- UK-based Aga Foodservice Group crosses the pond with its acquisition of Domain Home Fashions, a home furnishings retailer headquartered here, for $25 million.

MARLBOROUGH, MA- Newton, Massachusetts-based New England Development seeks a special permit to develop a 126,000-sf Target store on a 20-acre parcel it owns here right near Solomon Pond Mall. It's the second large development recently proposed for this town.