CAMBRIDGE, MA-Vertex Pharmaceuticals Inc. lays off 111 employees as it explores alternatives to its lease on 290,000 sf of space in Kendall Square. The drug company signed the lease two years ago.

MIAMI-The $18 million, 137,000-sf FedEx Miami Airport Gateway office and warehouse facility will replace a smaller facility and is designed to better position the company for growth. The projected completion date is this December.

CHARLOTTE, NC-The buyer, Harbor Group International of Norfolk, VA, plans on spending an additional $864,000 to upgrade the 18- building, garden-style development built in the early 1980s.

LONDON-Developer London Town has successfully overturned a planning decision refusing consent for a tower next to the Tate Modern gallery on the South Bank of the Thames in central London.