PHILADELPHIA—Hard details on lost jobs and new jobs coming to the region will likely become clearer in time as GlaxoSmithKline undertakes a consolidation of its research operations to suburban Philadelphia locations, but also implements job cuts at its commercial pharmaceutical operations here.

CHICAGO—But second-tier cities, including Asian and European ones, will begin to challenge US dominance in some areas within the next few years.

MIAMI—Bilzin Sumberg's Javier Avino tells GlobeSt.com's Jennifer LeClaire what's driving this trend in Miami Beach and beyond.

PHILADELPHIA —Accesso Partners LLC has acquired 1515 Market St., a 20-story, half-million square-foot office tower in downtown Philadelphia that houses Temple University's Center City campus, for $85 million.